Facebook Dr. Anil Home page AutismItsGutStupid
Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health
Altered flora has been implicated in many gastrointestinal as well as gastrointestinal disorders. Clostridium difficile is a ubiquitous organism and its infection has been hypothesized to be involved in many disorders including autism. C. difficile infection can sometimes be difficult to eradicate. Total gut flora transplantation is sometimes undertaken to get rid of refractory infection. Note: C. difficile may be seen in healthy adults and Asymptomatic subjects are not treated.
Is It Leaky Gut or Leaky Gut Syndrome?
Clostridium difficile
About 25% of C. difficile do not produce toxin. Anecdotal evidence suggests a beneficial role for oral administration of such nontoxic strains for treatment of recurrences. Attempts to imitate the use of cultured bacteria have mostly been unsuccessful since cultured bacteria frequently do not get establish in gut adequately.
Fecal bacteriotherapy
This involves transfer of entire bacterial flora from a healthy donor to the sick recipient. It has been used successfully to treat refractory as well as severe/recurrent cases of C. difficile colitis as well as inflammatory bowel disease (IBD).
Protocol
• Protocols/recipies vary. I am not aware of any randomized controlled trials to examine most issues related to fecal transplantation.
• Single as well as multiple sessions have been used
Enema administration of blenderized stool
• Amount of stool varies. For example, a single administration 5-10 gm homogenized stool in pasteurized cow's milk was reported to be successful in seven of nine patients although relief of diarrhea may be delayed for up to five days.
- Colonoscopic adminsteration
- Via nasogastric tube: A case series of 18 subjects reported that during the 90 days after nasogastric treatment with stool, 2 patients died of unrelated illnesses whereas only one of the 16 survivors suffered a single recurrence of C. difficile colitis26. Stool treatment did not have any adverse events associated with the treatment. No adverse effects associated with stool treatment were observed.
Is It Leaky Gut or Leaky Gut Syndrome?
Prerequisite studies in donor
• Healthy donor with normal formed stools
• Should not be close relative and/or living in same household
• No antibiotic use for prior at least 6 months
• Screen donor stool for bacterial, protozoal and viral pathogens.
• Complete blood count and comprehensive metabolic profile
• Exclude hepatitis A, B, and C; HIV and STD like syphilis
Pre-enema preparation of recipient patient
• Administer vancomycin 250 mg tid to 500 mg bid for 7 days. This vancomycin is not absorbed into the body and kills many but not all gut bacteria including C. difficile.
• Administer polyethylene glycol solution (1 gallon) day before therapy. Brand names include GoLytely(R) used a part of colonoscopy. This is meant to flush out colon so as to start afresh!
Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health
Example of a representative protocol
• Mix 200-300 g of donor stool in 250 ml of normal saline. Homogenize briefly in blender.
• Administer blended product within 10 minutes via retention enema with buttocks slightly raised by pillow to facilitate retention
• Encourage patient to change position every 15 minutes to faciliate the spread of transplanted stool all over colon
• Administer fecal enema daily for 5-7 days.
• First administration may be undertaken via colonoscope into the cecum and even terminal ileum to potentially enhance efficacy.
Is It Leaky Gut or Leaky Gut Syndrome?
Wall Street Journal Bestseller Dr. M's Seven-X Plan for Digestive Health
More topics of interest below
| All fish are not same: Low v high mercury fish | |
| Quinoa: one complete high protein food | Health benefits of probiotics and prebiotics |
| Oral health in autism: dental caries and gums gingivitis | FODMAP diet: one type of elimination diet to try |
| Zinc supplements boost immune sytem and reduce respiratory infections | Turmeric: A must-have healthy spice in kitchen. |
| Use of elimination diet in autism | Food allergies and intolerance are not the same |
| Do cranberry and/or mannose protect against urinary tract infections or UTI | Coconut oil repairs unhealthy skin |
