Dr. Karczewski and colleagues have demonstrated that probiotics strengthen leaky gut by altering the configuration of tight junctions of the intestinal fence barrier.
- Open labelled trial
- 29 patients
- Intervention: 2 g per day of the multi-strain probiotic (Ecologic®Barrier, 2.5×109 cfu/g) for 12 weeks
- 93% of patients completed the study
- B. bifidum W23
- B. lactis W52
- L. acidophilus W37
- L. brevis W63
- L. casei W56
- L. salivarius W24
- Lc lactis W19
- Lc. Lactis W58
- Frequency and intensity of migraine headache in a diary
- Migraine Disability Assessment Scale
- Henry Ford Hospital Headache Disability Inventory at baseline and after 12 weeks of treatment
- Significant decline in mean number of migraine days per month from 6.7 at baseline to 5.1 between weeks 58 and 8, and further to 5.2 during weeks 9-12.
- Significant decline in mean intensity/severity of migraine headaches from 6.3 at baseline to 5.5 at the end of trial
- Significant improvement in Migraine Disability Assessment Scale score improved from average 24.8 to 16.6.
- There was no difference in the Headache Disability Inventory score did not change.
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