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Colic is seen in about 25% of the infants especially in neurobehavioral disorders like autism and involves excessive crying. Parents are too familiar with abdominal colic in kids and the frustration it causes. It is a poorly understood entity and the parent’s frustration is further compounded by inadequate prevention and treatment options.
Is It Leaky Gut or Leaky Gut Syndrome?
Recent data implicates alterations of gut bacteria in causing the disease. A corollary to this would be that readjusting the balance of gut bacteria can help heal these kids of what sometimes seem like never ending crying spells.
Dr. de Weerth from the Behavioral Science Institute, Radboud University, Netherlands wished to examine if there are differences in the early on intestinal bacteria in kids with colic problems. There article titled, “Intestinal Microbiota of Infants With Colic: Development and Specific Signatures” was published in the journal Pediatrics.
Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health
Methods of colic-bacteria study
The investigators studied the the bacterial DNA from 12 colicky infants. The data was compared to similar age-matched infants without colic. More than 200 stool samples were taken from study subject and controls.
Results of colic-bacteria study
- Significant patterns of intestinal bacteria were found in colicky subjects
- There was increase in bacterial bio-diversity after birth in healthy subjects and not in colicky infants
- Bacterial groups responsible for colic-related differences in bacteria were evident in colicky subjects as early as 1-2 weeks after birth.
- Unhealthy bacteria of Proteobacteria type were increased more than 2-fold in colicky infants
- Healthy Bacteroidetes and Firmicutes including bifidobacteria and lactobacilli bacteria were decreased in infants with colic. Many of these are known to anti-inflammatory effects including increased production of butyrate in the colon which ahs been shown to affect pain in several studies. Dr. Banasiewicz have shown that administration of microencapsulated sodium butyrate reduces the frequency of abdominal pain in patients with irritable bowel syndrome.
Is It Leaky Gut or Leaky Gut Syndrome?
Dr. Minocha's comments
- Specific/unique intestinal bacterial fingerprint is evident early on within first couple of weeks in babies who later on develop colic.
- The dysbiosis likely results in chronic low grade inflammation, large amounts of intestinal gas and pain resulting in crying for extended periods at a time.
- Maternal diet during pregnancy and breast-feeding period may also play a role.
- The greater levels of bacteria that are big producers of butyrate among babies who do not develop colic later on provides clues to targeting therapies for crying seen in such babies, an obvious example would be the use of probiotics and prebiotics in the baby’s formula.
Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health
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Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health
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Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health
