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Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health
Kava kava akso known as kava Kava (Piper methysticum) root is widely used for treatment of anxiety, depression and insomnia. Several reports have implicated in several severe and even fatal cases of liver toxicity. Immune-allergic mechanisms are believed to be involved in liver toxicity.
The regulatory causality evaluation of the reported cases has been mired in debate in the scientific community. The Food and Drug Administration or FDA issued a customer advisory regarding the dangers of this agent in 2002. Its use is banned in several European countries.
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Many experts like Anke have challenged the concept of hepatotoxicity being caused by kava kava in many of the reported cases. In vitro data does not support a hepatotoxic potential. Many of the effected patients reported in literature were also taking other medications.
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Teschke in a thorough review published in Annals of Hepatology (2010) concluded that kava kava may be hepatotoxic in a few individuals due to overdose, prolonged treatment, co-medication, and probably triggered by an unacceptable quality of the kava raw material. A 6-point program to improve quality by standardization to prevent liver toxicity due to kava has been recommeded. |
Citation: Teschke R: Kava hepatotoxicity--a clinical review. Ann Hepatol. 2010;9(3):251-65.
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