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You have heard about botox or botulinum toxin for skin wrinkles. Even botox parties are celebrated. Seems funny considering its use in anal fissure? By the way, botox or botulinum toxin has other uses too, like in achalasia, gastroparesis due to pyloric spasm etc.
Anal fissure
Anal fissure (different from hemorrhoids) can really be a pain the rear (no pun intended). Although acute anal fissures can be managed by conservative measures alone, the optimal medical treatment for chronic anal fissure is still lacking.
Is It Leaky Gut or Leaky Gut Syndrome?
Surgery is effective for treatment of chronic anal fissure but has significant morbidity.
Botox or botulinum toxin for anal fissures
Recently, Brisinda and colleagues (Br J Surg 94:162-7) from Italy compared the efficacy of local nitroglycerin ointment versus botulinum toxin (botox).
Results
Botox group had superior healing rates at both 4 and 8 weeks. Adverse events were more likely to be due to nitroglycerin.
Bottomline
This finding of a comparison between two medical treatments must be interpreted in the context of data on comparison with placebo where nitroglycerin has only been marginally superior. In contrast, the efficacy of botox was similar to placebo.
Until long term studies can show superiority of botox over placebo, its use for routine treatment of chronic anal fissure may not be prudent.
Have you used botox for any reason? Do you or someone you know has chronic anal fissures? Please share the remedies that have or have not worked for you.
Here is info on botox or nitroglycerine for anal fissures.
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