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Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health
There has been an explosion in the market for over the counter heartburn drugs like antacids, alginate/antacid combinations as well as histamine-2 receptor blockers (H2B or H2RAs). The question arises, how effective are these OTC drugs?
Dr. Tran and colleagues from the Baylor College of Medicine in Houston, TX carried out a systematic review and meta-analysis of randomized placebo controlled trials related to these therapies. They published their findings in the journal Alimentary Pharmacology and Therapeutics (Jan 2007).
Is It Leaky Gut or Leaky Gut Syndrome?
Studies conducted with H2RAs showed superiority of these drugs with respect to complete relief of heartburn, symptomatic improvement, and episodes requiring rescue antacids. There was an absolute benefit increase of 10-12 percent with this class of medications.
Based on the four studies examining the antacids, the authors found a trend towards their effectiveness with an absolute benefit of 8 percent.
Similarly, 4 studies examining the demonstrated alginate/antacid combination found this class to be superior to placebo with an absolute benefit of 26 percent.
An amazing finding was the effect of placebo. The authors found that placebo response occurred in 37 to 65% of the cases.
Proton pump inhibitors like omeprazole are now available without a prescription. However, OTC omeprazole was not studied in this report.
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