Facebook Dr. Anil Home page AutismItsGutStupid
Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health
It is well documented that chronic stress makes the gut barrier hyperpermeable or leaky. This can allow the harmful substances including bacteria to leak across the gut wall and absorbed into the body causing disease.
Dr. Zareie and colleagues from Hospital for Sick Children, Canada sought to examine if this leakiness of the gut could be prevented by administration of a probiotic regimen in rats under chronic stress.
Is It Leaky Gut or Leaky Gut Syndrome?
Study: Chronic psychological stress was induced in rats by a test called water avoidance stress (WAS) which is known to make gut leaky. These rats were subjected to water avoidance stress or sham stress intermittently over a period of days.
Animals were given supplementation of probiotics Lactobacillus acidophilus and L. rhamnosus in the drinking water prior to stress. Animals remained healthy for the duration of the study. Rats were sacrificed after the study and the gut as well regional lymph nodes were studied.
Results: Chronic stress caused a intestinal barrier dysfunction (Leaky gut) in both small and large intestine along with increased bacterial stickiness to the lining of the gut wall as well as penetration across the gut wall. Over two-thirds of rats were found to have bacterial translocation to mesenteric lymph nodes.
While probiotic pre-treatment alone had no effect on intestinal barrier function in controls, the treatment reduced gut barrier dysfunction; in addition, it completely blocked the bacterial stickiness to the gut wall as well their translocation across the gut wall into the body.
Conclusions: These results further lend support to hypothesis that certain probiotics can prevent chronic stress-induced intestinal abnormalities and, hence have potential to reduce the potential for sicknesses e.g. irritable bowel syndrome and inflammatory bowel disease like Crohn's disease and ulcerative colitis.
Implications in humans: While it may be a big leap to jump to conclusions from a study involving rats, it should be noted that there is evidence suggesting that probiotics help in some patients with irritable bowel syndrome as well as ulcerative colitis in humans.
NOTE: All probiotics are not created equal!
Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health
More topics below or go to Home Page
Is toileting posture important? Taking care of business!
|
|
|
Does zinc reduce risk of pneumonia
|
Fish type, mercury toxicity & health v benefits: Farmed fish v wild
|
|
Food triggers for migraine and helpful natural supplements
|
|
Is VitaminD deficiency a growing epidemic. maybe?
|
Mangosteen is not the same as mango
|
Irritable bowel syndrome or IBS
|