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Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health
Despite the popular myth, the stomach despite its acidity is not completely sterile. The most common type of bacteria is known as Helicobacter pylori (Hp).
Ever since the then controversial publication by Nobel laureates Warren and Marshall correlating these bacteria with gastritis and ulcers, this bacterium has been a subject of countless research papers as well as speculation. It has been linked to controversial conditions like coronary artery disease and short stature
H. pylori is a ubiquitous organism and may be present in as many as 40-50% of the population. In some developing countries, the prevalence may be as high as 90 percent. In most humans, it does not appear to cause any health problems.
Is It Leaky Gut or Leaky Gut Syndrome?
PROVEN ASSOCIATIONS
- Gastritis
- Duodenal ulcer and gastric ulcer
- Gastric adenocarcinoma (World Health Organization classifies Helicobater pylori as Class I carcinogen)
- MALT-lymphoma
Preliminary data suggests the association with the following:
DIAGNOSIS
The diagnosis of Helicobacter pylori can be made by a variety of means including testing the biopsy specimen obtained on upper GI endoscopy. Other methods include breath test and stool test. The above tests look for evidence of actual presence of the H. pylori bacteria. A simple indirect screening test involves testing the blood for antibodies against the Helicobacter pylori. However, the latter can't be used for testing for results of eradication therapy since the antibodies may persist in the blood long time (months to years) after the Helicobacter pylori has been eradicated.
Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health
TREATMENT
Helicobacter pylori is a very resistant organism. As such, multi-drug regimens usually taken for 2 weeks are the rule. Variety of drug combinations comprising of 3-4 drugs are available. Dose-packs are also available, e.g. PrevPac and Helidac. Dosepacks improve compliance. Probiotics may help reduce the severity of side-effects due to treatment.
Paradoxically, some studies suggest that Helicobacter pylori is protective against gastroesophageal reflux disease or chronic heartburn.
Of note: Many experts recommend 4-drug regimens to eradicate H. pylori.
TREATMENT SUCCESS
Success rates vary and depend on multiple factors including the drug regimen and compliance etc. Re-infection rates are low in developed countries (less than 5%) but may be as high as 20% in developing countries.
Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health
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