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What is D-ribose
- D-ribose is a natural carbohydrate.
- It blocks the generation of harmful free radicals.
- It enhances the energy potential of the cells. D-ribose restocks the depleted energy levels in tissues and improves tissue function.
- D-ribose has anti-inflammatory activities and protects against damage mediated via inflammation.
- A typical diet may be deficient in D-ribose.
- D-ribose supplements offer a pragmatic strategy to increase D-ribose in the body.
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D-Ribose and brain
- Ribose is involved with CD38 system in the brain and as such participates in social behavioral regulation.
- ADP-ribose generated in the brain contributes to repair of the damaged DNA.
What is CD38
- CD38 is a multifunctional enzyme found in many immune cells including white blood cells as well as natural killer cells.
- CD38 system is intimately involved with functioning of the hypothalamus part of the brain and as such forms part of biological basis for social recognition, trust, and bonding.
- A dysfunctional CD38 in the brain thus can lead to abnormal social behavior.
Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health
What is Poly(ADP-ribose) polymerase 1
- Poly(ADP-ribose) polymerase 1 is a ribose related enzyme and part of DNA damage surveillance network protecting against DNA damage. Significant activation of the enzyme depletes the cells of energy stores causing cell damage or death. These enzymes may act as molecular switch for cell survival and death.
- Blocking this enzyme reduces oxidative stress and brain damage in animal models of brain injury.
Protective role of D-ribose in heart
- D-ribose protects heart against damage by re-energizing damaged cardiac cells in mice.
- Evidence supports benefits of D-ribose in patients with heart disease including heart failure.
Is It Leaky Gut or Leaky Gut Syndrome?
Common mechanism/pathways of brain dysfunction/damage
- Brain damage in disorders like stroke, trauma involve multiple mechanisms including oxidative stress and inflammation.
- Defective enzymes and abnormal metabolic reactions have been described in autism. Specifically, oxidative stress, mitochondrial dysfunction and energy deficits are seen in many kids with autism and ADHD.
- The increased oxidative stress stimulates the ribose related enzyme poly (ADP-ribose) polymerase-1 in brain cells exhausting the energy stores causing brain damage.
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Dose of D-ribose
- A dose of 5 g three times a day (adults) improves symptoms in fibromyalgia as well as chronic fatigue syndrome. The benefit is seen in sleep; mental clarity; pain intensity; and overall well-being.
- Same dose of 5g 2-3 times a day has been used with benefit in restless leg syndrome.
- While there is no literature to suggest a particular dose in children, half of the adult dose for kids between 1 and 8 years of age may be appropriate. Always check with your doctor first.
Is It Leaky Gut or Leaky Gut Syndrome?
Conclusion about D-ribose and antioxidants
- According to Dr. Addis and colleagues from the University of Minnesota, a combination of D-ribose plus antioxidants provides an optimal state of cellular protection against damage related to oxidative stress.
- Although there is no direct data, extrapolation from studies on patients with fibromyalgia and chronic fatigue syndrome suggests that D-ribose has potential to help kids with autism and ADD/ADHD via replenishment of their exhausted energy stores leading to improvement in symptoms.
Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health
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Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health
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