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Role of Unhealthy Microbiome and Intestinal Infantile Colic
Traditionally, family psychodynamics, family bonding etc. have been implicated in pathogenesis of infantile colic. Use of modern molecular probes has shown that there is significant dysbiosis in these patients.
de Weerth and colleagues compared the microbial DNA of more than 200 samples from 12 infants with intestinal colic and 12 age-matched control infants. These investigators found that bacterial diversity increased only the healthy control babies and not in those with colic.
Samples were also less stable during the first few weeks in those with colic. Differences in bacterial patterns could be seen as early as week 1 or 2 of life.
The number of Proteobacteria is was more than 2 times higher in babies with colic as compared with control infants. The number of bifidobacteria and lactobacilli were significantly reduced in colic group.
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Dubois conducted an integrative review of literature and confirmed above findings. Specifically, the intestines in these patients exhibit greater numbers of Proteobacteria and significantly lower diversity of intestinal bacteria overall as compared to healthy subjects.
Research also indicates that fewer the Actinobacteria Bifidobacterium and Firmicute Lactobacilli bacteria, the greater the crying and fussiness in babies. Such changes are significant because the imbalance is being created as a result of bacteria not normally abundant in the gut.
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Facebook Dr. Anil Home page AutismItsGutStupid
FREE at Barnes & Noble: Doctor's Guide to Milk and Your Health: The Good, The Bad or The Slow Poison
Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health
Is It Leaky Gut or Leaky Gut Syndrome?
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