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Seizure disorder is frequently seen in patients with autism.
Study
Recently an international expert panel led by Dr. Frye from the Arkansas Children’s Hospital Research Institute, Little Rock, AR conducted a systematic review of medical literature on the effectiveness of various therapies for seizure disorder in autism.
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Study concerns
They lamented at “the striking lack of clinical trials performed to support the use of these treatments”.
Study results
They drew the following conclusions from the limited literature available. The grade of evidence for effectiveness in autism with seizures is provided on a scale of A to D.
Most effective drugs for epilepsy in autism in general
Valproate (C)
Lamotrigine (C)
Levetiracetam (C)
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Non-drug treatments (limited evidence)
- Ketogenic (C)
- Modified Atkins diet (C)
- Surgery, mostly multiple subpial transections (C)
- Neurofeedback treatment (C)
Auism associated with mitochondrial disorders and dysfunction (limited evidence)
- L-carnitine
- Multivitamins
- N-acetyl-l-cysteine
Autism associated with tuberous sclerosis complex
- Vigabatrin (C)
- Abnormal folate in brain (limited evidence)
- Folinic acid (C)
Novel treatments (limited evidence)
- Magnesium with pyridoxine (D)
- Omega-3 fatty acids
- Gluten-free casein-free diet (C)
- Low-frequency repetitive transcranial magnetic simulation
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Novel treatments (supported by basic science)
- Zinc
- L-carnosine
Dr. Minocha’s comments
Overall the literature is limited at best. Patient characteristics of autistic symptoms plus seizures would guide the treatment with medications and non-traditional therapies as a valuable adjunct. More studies are sorely needed to identify effective treatment of seizures in patients with autism.
Getting treatments to help deal with your seizures is very important and can make all the difference in the world to get. That way you do not have to deal with things on your own and you can really start getting on top of things. There are all kinds of seizure support companies out there that are more than willing to help you out when you are in need.
http://www.transformationchiropractic.com/testimonials/seizures-epilepsy/
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