Probiotics improve memory, cognitive function

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There are many studies suggesting affect of neurological function in animals. Dr. Benton and colleagues  from the University of Wales Swansea, UK studied the effect of a probiotic drink on mood and memory and demonstrated a beneficial  impact.

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Study design:

• Double blind placebo controlled trial for 3 weeks
• Intervention: Probiotic drink supplied by Yakult ® containing Lactobacilus casei Shirota in milk, water and sugar. Each ml of the drink contained 6.5x109 bacteria.
• Measurements were done prior to trial and then 10 and 20 days after

Data analyzed:

1. Mood was assessed by POMS test questionnaire comprising of 72 adjectives spread over 6 domains (energetic/tired, clearheaded/muddled, composed/anxious, confident/unsure, elated/depressed and agreeable/angry.

2. Episodic memory

3. Long term memory

4. Verbal fluency

5. Eating related social behavior

6. NART to measure of intelligence

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Analysis:

Since majority of the subjects scored above average on mood at baseline, the analysis focused on those in the bottom 1/3rd of the subjects

Results:

1. Subjects who were constipated less frequently were more clearheaded, confident, and elated. The measures of higher energetic scores showed trend towards statistical significance..

2. Probiotic improved mood in those with low POMS depressed/elated scores.

3. Probiotic improved memory at 20 days. Those with failing memory appeared to benefit more.

4. There was no effect on verbals fluency

5. Probiotic did not improve eating related problems. However, the negative esult may be due to low baseline incidence of eating problems in this otherwise healthy population.

Dr. Minocha's comment:

Is It Leaky Gut or Leaky Gut Syndrome?

Constipation is associated with psychological dysfunction. This study confirms that probiotics can improve brain function including memory, mood in as few as 3 weeks. However, it should be pointed out that effects of probiotics are strain specific and the results from one probiotic strain may not necessarily be translated into effects for another.

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