Digestion, health and nutrition: Dr. Anil Minocha, a gastroenterologist and nutritionist

Testosterone and mortality, cancer screening in rural vs urban population

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Testosterone level:

Low testosterone levels can be double whammy! As if low testosterone levels are not bad enough for men for obvious reasons, they are also likely to increase risk of death. Khaw and colleagues based their conclusions about relationship between between testosterone concentrations and mortality in a case-control study of 11,606 men aged 40 to 79 years surveyed in 1993 to 1997 and followed up to 2003. Similar results have been recently reported by Haring and colleagues in European Heart Journal.

Is It Leaky Gut or Leaky Gut Syndrome?

Pedometer for weight management:

If you are interested in weight management, use pedometer when walking rather than walking without one. Its use encourages more walking and more weight loss. Richardson and coleagues performed a meta-analysis of nine studies with a sample size ranged from 15 to 106, for a total of 307 subjects.  Subjects lost a mean 0.05 kg per week during the intervention. The authors concluded that pedometer-based walking programs result in a modest amount of weight loss. Longer programs lead to more weight loss than shorter programs.

Cancer screening:

Who do you think misses out on cancer screenings, rural or urban population? If you guessed rural, you may be wrong, so suggests a study from Dartmouth-Hitchcock Medical Center. Paquette and colleagues  performed a retrospective, descriptive analysis of cancer stage at presentation of rural versus urban patients with lung or colorectal cancer using the Surveillance, Epidemiology, and End Results database from the National Cancer Institute. 

Logistic regression analysis revealed that urban patients are more likely to present with late-stage colorectal and lung cancer when compared to their with rural counterparts.  Other studies suggest that the relationship between Socioeconomic status and the risk of late stage colorectal cancer varies among rural and urban populations.

Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

More topics of interest.....

Probiotics de-stress gut dysfunction	Antibiotics in meat: A case for organic food
Overview of autism spectrum disorders	Unhealthy gut and digestion are at root of many chronic diseases
Desulfovibrio: The new bad actor on autism scene	Abnormal gluten gliadin antibodies In autism
Functioning brain MRI scan evidence probiotics affect brain changes	D-ribose re-energizes brain in autism, ADHD
Autism is rising in developing countries too	Probiotics improve brain function, mood, memory
Intergenerational effects: Implications for chronic diseases like autism	Altered Fermentation of Undigested Food by Gut Bacteria in Autism: Clues to Treatment Strategies
Warning signs of autism	Does Influenza and Antibiotic Use During Pregnancy Increase  Autism
Does proximity to freeway traffic  increase risk of autism	Ketogenic diet and autism
Moms' Probiotic Use Reduces Eczema	Effect of Gut Bacteria on Ultimate Health Starts During Pregnancy

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Birth control, childhood hygiene, IBD, obesity, premature death

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Condom distribution

According to Margie Mason of the Associated Press and published in numerous newspapers, some mullahs in Afghanistan are distributing condoms while others are quoting the holy Quran to encourage longer intervals between births. 

FDA recall

The Food and Drug Adminsteration is recalling numerous food products because of contamination with the bacteria, various parts of media is reporting. This is used in a variety of soups, sauces, chilis, stews, hot dogs, snacks, dips, and dressings. However, this contamination has not been associated with any episodes of sickness thus far. Per the report, the FDA traced this contamination to Las Vegas-based Basic Food Flavors.

Childhood hygiene and inflammatory bowel disease

A Population-based study by Klement and colleagues from Israel and published in American Journal of Gastroenterology found that childhood hygiene Is associated with the risk for inflammatory bowel disease. Lacatos states that cold chain hypothesis is providing an even broader platform by linking dietary factors and microbial agents. 

 Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

Obese children and premature death

Obese children have an increased increased risk of premature death from endogenous. This was reported in the New England Journal of Medicine. Other factors for premature death included  glucose intolerance and hypertension during childhood. 

Malnutrition is common in hospital

Multiple studies have documented  high prevalence of malnutrition and poor intake in patients who had fallen in hospital. Nutrition assessment nutritional intervention is often neglected but should be undertaken aggressively. Family members beware: Hiesmayr and colleagues report that hospitalised patients eat less food than provided as regular meal and this reduced intake increases risk for death in the hospital. 

Heartburn, GERD and acid reflux	Probiotics in IBS or irritable bowel syndrome
Stroke prevention diet	Yogurt heals kids diarrhea
When should I have a repeat colonoscopy?	Baked or broiled fish protects against abnormal heart rhythms
Could your birthday be a risk for stroke?	Irritable bowel syndrome or IBS and Chinese herbal medicine
Can restaurants help cure obesity?	Does coffee protect liver?
Does Mediterranean diet increase longevity?	Does stress cause leaky gut syndrome?
Intestinal bacteria and infantile colic	Cranberry juice versus antibiotics for urinary tract infections

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BMI, hepatitis, CAM, inflammatory bowel disease, antioxidant defense

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Systemic review of weight loss strategies for under five year old was conducted by Bond and colleagues.  Of the four randomized controlled trials, only one found a statistically significant benefit from the intervention slowing rate of increase in body mass index. Other studies did show a trend for BMI and loss in weight improvement.  

A recent study by Malgorzata Krzystek-Korpacka and colleagues documented that antioxidant defenses of red blood cells are impaired in patients with inflammatory bowel disease. 

Jain and colleagues have shown that there is increased oxidative stress and a compromised antioxidant defence system in smokers as compared to nonsmokers.

A recent cross-sectional pilot study by Erlichman and colleagues examined the use of complimentary and alternative (CAM) in 68 children with chronic viral hepatitis. Forty-six percent of these kids had used CAM at least once since diagnosis with chronic viral hepatitis and 31% used CAM monthly or more frequently. Herbals and dietary supplements were used most often. 

Some more topics of interest or click to go to Home page

feeding disorders anorexia nervosa and bulimia	Whole fruit against fruit juice. What should you take?
Melatonin  is not just for sleep: use for healthy digestion	Is mangosteen healthy and does it prevent sickness?
Chronic back pain? Acupuncture may be the answer	Homeopathy for fibromyalgia
Are you overwright or obese? Bacteria in your colon may be the issue!	Healthy travel, prevent motion sickness
Breast feeding merits, alternatives	Yoga improves sex in both genders
Acupuncture for chronic heartburn?	Folic acid or folate supplements to prevent cancer is somewhat controversial.
Reduce mortality with this vegetarian diet and treat obesity too	Drink tea to improve health?

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Fiber formula diet prevents gut infection

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The gastrointestinal tract is full of bacteria, more so in colon than other parts of gut. Normal bacteria play a variety of beneficial roles in the body including enhancing immune function and preventing infections.

Clostridium difficile (C. difficile) is a common cause of nosocomial diarrhea including antibiotic-associated diarrhea. Lately, this bacteria has become increasingly virulent resulting in increased relapses as well as greater morbidity and mortality. The recurrences of Clostridium difficile infection can be so severe that total bacterial flora replacement or transplant from healthy donor may be needed.

Is It Leaky Gut or Leaky Gut Syndrome?

A less recognized cause of Clostridium difficile diarrhea, in addition to use of proton pump inhibitors or PPIs like Nexium, Prevacid, Protonix or Prilosec etc., is the increasing use of elemental diets in formula  fed hospitalized patients over extended periods. Since most if not all of the elemental diet is absorbed in the small intestine, it deprives the colonocytes as well as the colonic bacteria of their source of nutrition. These sources of nutrition in a healthy diet include prebiotics like dietary fiber, fructo-ogosaccharides, and resistant starch.

Dr. O’Keefe states that lack of bacterial fermentation in the colon leads to suppression imbalance of good versus bad bacteria or dysbioisis. The good bacteria include butyrate-producers and bifidobacteria. Such dysbioisis is unhealthy and leads to permissive environment for C. difficile which overwhelms the gastrointestinal immune defenses. This allows these harmful bacteria to colonize and proliferation leading to infection.

As such, a change of tube feeding formula from elemental diet to a prebiotic or fiber containing diet as soon a possible has potential to reduce the prevalence and severity of C. difficile induced infection.

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Colon cancer risk prevention by colonoscopy

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 Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

Colonoscopy is considered the gold standard for screening for colon polyps and cancer. It is recommended and paid for by many third payor parties including Medicare. Few people realize that  there is paucity of randomized trials supporting the benefit of colonoscopy Few realize that there has been paucity of direct evidence in support of concept that colonoscopy would help reduce colon cancer and its resultant morbidity and mortality.

Current estimates of the effect of colonoscopy on CRC incidence—an estimated reduction of 76% to 90% reduction of incidence colon cancer as a result of colonscopy is based on data from national polyp study which lacked concurrent controls.

Is It Leaky Gut or Leaky Gut Syndrome?

However, recently a few studies have cast a doubt on the presumed effectiveness of colonoscopy with respect to reducing risk of right sided colon cancers. This was supposed to be the advantage of colonoscopy over sigmoidoscopy.

Brenner and colleagues wished to determine if a prior colonoscopy compared with no colonoscopy was associated with reduced prevalence of advanced colorectal neoplasms (defined as cancers or advanced adenomas).This population based study involved a statewide cross-sectional study of 3287 subjects 55 years or older from Germany. Prevalence of advanced colorectal neoplasms was assessed by screening colonoscopy and histopathologic examination of the lesions. 

Advanced colorectal neoplasms were found in 11.4% of the 2701 subjects without prior colonoscopy as compared 6.1% who had undergone colonoscopy within the preceding 10 years. Overall and site-specific adjusted prevalence ratios for previous colonoscopy demonstrated that the colonoscopy in the prior 10 years was associated with a reduction in prevalence of left-sided advanced colorectal neoplasms, but not right-sided advanced neoplasms.

Another study was performed by Baxter and colleagues. They conducted a population-based, case-control study to examine the effectiveness of colonoscopy for preventing deaths related to colorectal cancer in Ontario, Canada. The authors identified 10, 292 case patients and 51, 460 controls from administrative claims data. 7.0% of patients and 9.8% of the controls had previously undergone a colonoscopy. Logistic regression showed that colonoscopy was significantly associated with fewer deaths from left-sided colorectal cancer (Odds ratio 0.33; C.I. 0.28 to o.39) but not from right-sided colorectal cancer.

Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

Above studies may call into question the beneficial value of colonoscopy for colorectal cancer screening. Ranshoff argues that based on these data, we should probably tell our patients that high quality colonoscopy results in a 60% to 70% reduction iof the risk for death from colorectal cancer as opposed to 90% reduction that has been largely assumed.

Above Ranshoff suggestion notwithstanding, an even more important question may be whether the widespread use of colonoscopy as the screening method is actually a cost-effective versus a grossly wasteful method of screening. Colonoscopy has a much higher risk for significant complications as compared to other cancer screening modalities. An extreme view might be that colonoscopy as a primary tool of colon cancer screening is a misuse of health care dollars and that flexible sigmidoscopy should suffice in average risk subjects. 

Is It Leaky Gut or Leaky Gut Syndrome?

Obviously, such confusion and controversy has occured because of the use of colonoscopy based on indirect data and now we have poulation based studies challenging the degree of its effectivensss. Only large randomized controlled trials can help answer these vexing questions.

In the meantime, is there a significant incremental benefit of colonoscopy over flexible sigmoidoscopy for colorectal cancer screening? Is the magnitude of increased benefit from colonoscopy as compared to flexible sigmoidoscopy sufficient to justify the huge increase in cost, not to mention the additional risk for complications.

Baxter and Rabeneck argue that as more observational evidence accumulates, the answer to this question becomes less certain. Is it time to set up an expert panel to re-examine the issue whether the colonoscopy offers substantial benefit over flexible sigmoidoscopy in a cost effective manner.

What are your views on the above studies and resultant controversy? please share your thoughts.

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Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

Toileting posture for constipation

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Toileting posture?

Wonder what toileting posture implies? Think it is important for good bowel function? While the toileting posture may be non-issue for some, it could be crucial for those with constipation.

Is It Leaky Gut or Leaky Gut Syndrome?

How it may help?

Toileting posture is a modifiable factor that can be used as a part of an overall management strategy. The use of traditional toilet seats has potential to make recto-anal angle more acute contributing to difficult passage of stools and constipation

Patients best helped

This is particularly an issue in kids who sit with their legs dangling the air as well as the physically challenged subjects who need to use higher chairs in order to be able to get up after defecations. Constipation as kids has potential to persist throughout life. Appropriate toilet posture coupled with abdominal exercises may help in some cases of difficult defecation and constipation.

Regular physical activity, along with appropriate toileting posture (bending forward), support of the feet while seated on toilet and simple pelvic floor exercises, should be as part of an overall treatment plan for constipation.

Do you or someone you know have constipation? How is your toileting posture? Do you think the issue of toileting posture makes sense? Please share your thoughts.

*Further reading on kinky colon or dolichocolon 

Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

Turmeric, curcumin in ulcerative colitis

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Turmeric curry powder in inflammatory bowel disease 

Curcumin is a biologically active phytochemical component in turmeric or yellow curry powder and has been found to be effective in numerous diseases including cancer. Ulcerative colitis (one form of inflammatory bowel disease) may be one of those conditions with proven benefit.

Is It Leaky Gut or Leaky Gut Syndrome?

The study below was discussed at one of the sessions at the annual Digestive Diseases week (2008) which is the largest gathering of the gastroenterologists in the world. The two panelists (Dr. Koratz from UCLA and Dr. Mullen from Johns Hopkins) gave two thumbs up to this study of turmeric and endorsed its used in ulcerative colitis.

Hanai and colleagues studied the effect of turmeric (curcumin) as a maintenance therapy for ulcerative colitis in a randomized controlled fashion. They reported their findings in the journal Clinical Gastroenterology & Hepatology in a study titled, "Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial."89 with ulcerative colitis in remisssion participated in the study. Patients received curcumin (1g twice a day) or placebo in addition to the standard treatment (sulfasalazine or mesalamine) for 6 months.

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Of the patients receiving curcumin, 5% relapsed as compared to 21% in the placebo group.

The investigators concluded that curcumin seems to be a promising and safe medication for maintaining remission in ulcerative colitis. 

What are your thoughts on the above study and the action of a "natural remedy" being endorsed at a prominent medical scientific meeting? Please share your thoughts.

An update: Recent data indicates that curcumin is also effective in healing active ulcerative colitis

Is It Leaky Gut or Leaky Gut Syndrome?

Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

Heartburn, GERD and acid reflux	Probiotics in IBS or irritable bowel syndrome
Stroke prevention diet	Yogurt heals kids diarrhea
When should I have a repeat colonoscopy?	Baked or broiled fish protects against abnormal heart rhythms
Could your birthday be a risk for stroke?	Irritable bowel syndrome or IBS and Chinese herbal medicine
Can restaurants help cure obesity?	Does coffee protect liver?
Does Mediterranean diet increase longevity?	Does stress cause leaky gut syndrome?
Intestinal bacteria and infantile colic	Cranberry juice versus antibiotics for urinary tract infections

 Is It Leaky Gut or Leaky Gut Syndrome?

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Probiotics restore gut dysfunction, strengthen leaky gut	Health benefits of probiotics and prebiotics
Celiac sprue	Does zinc reduce risk of pneumonia
Is kava kava bad for liver?	Fish type, mercury toxicity & health v benefits: Farmed fish vs wild fish
Is fasting good or bad for health	Food triggers for migraine and helpful natural supplements
Is Vitamin D deficiency a growing epidemic. maybe?	Mangosteen is not the same as mango
Autism and your gut bacteria	Irritable bowel syndrome or IBS
Is folic acid supplement good or bad for cancer?	Eat fast, get fat

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Stool stasis, autointoxication due to fecal matter

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Undigested food staying in gut too long, creating toxins leading to disease--have you heard of this?

 The phenomenon is known as autointoxication and has its origins in ancient Egyptian civilization as far back as 16th century BC. Sir William Lane in the early 20th century in his treatise published in the Proceedings of the Royal Society of Medicine (1913) asserted that "autointoxication is the cause of all the chronic diseases of civilization".

Is It Leaky Gut or Leaky Gut Syndrome?

Is this concept of autointoxication a fact or a myth?  The proponents argue that slowed gut transit or increased stasis of fecal matter in the colon results in greater putrefaction and production of toxins. These toxins get absorbed and cause chronic illnesses with or without low grade inflammation.

It is difficult to demonstrate such a toxin experimentally especially since such a toxin(s) may not be universally present. It is entirely possible that a multitude of toxins is involved and the disease results from individual susceptibility. Furthermore, there may not be a special toxin, but the disease may be a consequence of some normal product of bacterial putrefaction that is not necessarily absorbed but has a direct action on colonic wall affecting the gut immune cells, endocrine-neuro-immune system and ultimately the entire body system. In addition to all the above unknowns, we cannot exclude the possibility of yet unknown toxin being involved.

So what is the verdict? Is the concept of autointoxication a hard fact or just a myth perpetuated by "quacks" over the centuries. We do not have the perfect answer, atleast not yet. One thing we do know however that having a regular, efficient bowel movement pattern is essential for positive health.

What are your thoughts on autointoxication? Do you or someone you know believe in and practice any methods  to counter it? Please share your thoughts.

Following topics may be of interest to you as well......

Does stress cause leaky gut?	Is rosacea of skin linked to the gut?
Preserve sexual function, prevent sexual dysfunction	Curcumin or turmeric for ulcerative colitis
Is gut structure and function abnormal in autism?	Health benefits of olive oil: Do you know how to pick one?
Does behavioral therapy benefit high blood pressure or hypertension?	How to prevent and heal indigestion.
Improve sex drive with these foods	Vitamin D deficiency and risk of autism
Does vegan diet improve diabetes control?	Can grapefruit help help you lose weight?
Autism, digestive enzymes and gut bacteria: Connecting the dots	Effect of probiotics on brain function: Multiple sclerosis analogy
Does mangosteen help your health? It is not the same as mango!	Does yogurt help Diarrhea in kids
Is sharing toothbrush harmful?	Natural plant products to repair aging skin
Role of teeth and gums in autism	Does yoga help back pain?
Lower Levels of pesticides and bacteria in organic food	Do hot dogs increase cancer risk?
Your microbiome and your risk of lung cancer	Does vegetarian diet increase brain power?
Are there healthy sweet alternatives to the sugar devil?	Propionic acid is the connecting link between diet, gut bacteria with brain dysfunction.

Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

 

Chronic low back pain: Tried acupuncture?	Chronic acid reflux and acupuncture?
Vegetarian diet: Does it affect mortality?	Natural treatments of depression
Got Migraine? Food triggers and natural treatments!	FODMAP diet: one type of elimination diet to try
Gut bacteria in fetus and future health?	Constipation: How to take care of business
Intestinal gas: Do you have it?	Vitamin D deficiency is common: You may have it!
Do cranberry and/or mannose protect against urinary tract infections or UTI	Leaky gut syndrome

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Enjoy apple to prevent colon cancer

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Does apple help health or is it a myth? Can it help against cancer? Do apple pectin and juice extract produce anticarcinogens during the fermentation in the colon? The answer seems to be yes.

Is It Leaky Gut or Leaky Gut Syndrome?

Dr. Waldecker and colleagues in the journal Nutrition studied the fermentation supernatants from incubation of human fecal slurry with apple pectin and apple juice extracts. The Inhibition of the enzyme histone deacetylase (HDAC) seems to play a central role in these anticancer effects. The authors found that  fecal slurry from fermentations with pectin was rich in butyrate and very active in HDAC inhibition in colon tumor cell lines.

The HDAC-inhibitory potency from pectin-rich fermentations correlated with the butyrate levels. Fecal slurry from fermentations with apple juice extract had lower butyrate yields but similar HDAC inhibition and potentially similar anticarcinogenic effect.

Is It Leaky Gut or Leaky Gut Syndrome?

This is how it works: Apple fermentation leads to increase in short chain fatty acids like butyrate. Butyrate is a chemopreventive metabolite that can prevent the occurrence of colorectal cancer. The mechanism is via inhibition of histone deacetylase leading to retarding the carcinogensis, the process of tumor formation.

The authors concluded that apple products exert anticarginogenic effects in the colon.

What are your thoughts about fruit in general and apple in particular? Are you going to go more for fruits or apples in the grocery store? Please share your thoughts. 

Topics below may also be of interest to you...or click to go to Home page 

Toileting posture to take care of business	Fructose sweetener and weight control: Good, bad or ugly?
Morning sickness or Nausea, vomiting of pregnancy	Chronic abdominal pain in kids
Do antioxidants lower cancer risk	Is folic acid supplementation, good or bad
Do zinc supplements help respiratory infection	Eat fast, get fat: control your weight
Black raspberries and cancer risk http://goo.gl/DvW3j	Diet for Crohn’s disease patients
Irritable bowel syndrome or IBS	Cancer risk of artificial sweeteners

Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

Kid getting frequent infections? Probiotics may help	Botox is not just for wrinkles on face: Useful for anal fissures?
Bacteria inside gut are a microuniverse with health and disease implications.	Treatment of internet sex addiction
Causes and treatment of hiccups	Glutamine and immune system
Natural aphrodisiac foods	Diet as risk for Crohn’s disease
Cancer risk of artificial sweeteners	Cognitive behavioral therapy CBT for Irritable Bowel Syndrome
GERD acupuncture treatment	Placebo pain relievers and price

How to prevent alcohol hangover	Homeopathy: Is it fact or fiction?
Natural treatments of migraine?	Have intestinal gas ?
Food allergies?	Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health
Do you know what is colitis and diverticulitis	Aphrodisiac foods to make your day  or night?
Constipation: How to take care of business!	Do artificial sweeteners increase risk of cancer?

 

Chronic low back pain: Tried acupuncture?	Chronic acid reflux and acupuncture?
Vegetarian diet: Does it affect mortality?	Natural treatments of depression
Got Migraine? Food triggers and natural treatments!	FODMAP diet: one type of elimination diet to try
Gut bacteria in fetus and future health?	Constipation: How to take care of business
Intestinal gas: Do you have it?	Vitamin D deficiency is common: You may have it!
Do cranberry and/or mannose protect against urinary tract infections or UTI	Leaky gut syndrome

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Can organic food heal inflammation: The Crohn’s disease model

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Organic food—expensive! Should we eat this expensive organic food for better health in Crohn’s?

Study question: Would organic diet be better for healing Crohn’s?

Gasche and colleagues from Austria tested the hypothesis that organic diet is better for treating Crohn’s disease.

Is It Leaky Gut or Leaky Gut Syndrome?

Patients with Crohn’s received organic diet or a control diet (low-fiber, low-fat, and high-carbohydrate). Outcome measures included MRI, endoscopy, Crohn's Disease Activity Index (CDAI), and the Inflammatory Bowel Disease Questionnaire (IBDQ).

Organic food diet showed improvement in their intestinal lesions not seen in patients assigned to a high-carbohydrate diet. The investigators concluded that food as part of the modern Western lifestyle may cause persistence of intestinal Crohn's lesions.

Diet and environmental have been linked to risk for Crohn’s disease. Diet and environment are not mutually exclusive. The increase in incidence of Crohn’s disease in recent decades suggests environmental risk factors associated with a Western lifestyle may contribute to Crohn’s disease.

What kind of diet do you prefer? Would you be willing to spend more for organic food in your diet based on this study?

Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

Topics below may also be of interest to you...or click to go to Home page 

Toileting posture to take care of business	Fructose sweetener and weight control: Good, bad or ugly?
Morning sickness or Nausea, vomiting of pregnancy	Chronic abdominal pain in kids
Do antioxidants lower cancer risk	Is folic acid supplementation, good or bad
Do zinc supplements help respiratory infection	Eat fast, get fat: control your weight
Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health	Diet for Crohn’s disease patients
Irritable bowel syndrome or IBS	Cancer risk of artificial sweeteners

 

Kid getting frequent infections? Probiotics may help	Botox is not just for wrinkles on face: Useful for anal fissures?
Bacteria inside gut are a microuniverse with health and disease implications.	Treatment of internet sex addiction
Causes and treatment of hiccups	Glutamine and immune system
Natural aphrodisiac foods	Diet as risk for Crohn’s disease
Cancer risk of artificial sweeteners	Cognitive behavioral therapy CBT for Irritable Bowel Syndrome
GERD acupuncture treatment	Placebo pain relievers and price

How to prevent alcohol hangover	Homeopathy: Is it fact or fiction?
Natural treatments of migraine?	Have intestinal gas ?
Food allergies?	Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health
Do you know what is colitis and diverticulitis	Aphrodisiac foods to make your day  or night?
Constipation: How to take care of business!	Do artificial sweeteners increase risk of cancer?

 

Chronic low back pain: Tried acupuncture?	Chronic acid reflux and acupuncture?
Vegetarian diet: Does it affect mortality?	Natural treatments of depression
Got Migraine? Food triggers and natural treatments!	FODMAP diet: one type of elimination diet to try
Gut bacteria in fetus and future health?	Constipation: How to take care of business
Intestinal gas: Do you have it?	Vitamin D deficiency is common: You may have it!
Do cranberry and/or mannose protect against urinary tract infections or UTI	Leaky gut syndrome

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Diet & Crohn’s disease risk

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Diet as risk for Crohn’s disease?

Over the years, some dietary foods predominant in vegetables and fruit have been thought of as protective. In contrast, fatty foods have been thought as increasing the risk for Crohn's disease. The literature however has been inconsistent. As such, the controversy continues as the precise cause of Crohn’s disease remains an enigma.

Dr. D’Souza and colleagues from Canada reported the results of their study in Inflammatory Bowel Diseases 2008. They examined the dietary patterns and risk for Crohn's disease in children in a case-control study fashion. Subjects included newly diagnosed Crohn’s disease compared with population and/or hospital-based controls.

Dietary patterns were assessed using a food frequency questionnaire. The study comprised of 149 cases of Crohn’s disease and 251 controls.

Is It Leaky Gut or Leaky Gut Syndrome?

Girls consuming diet consisting of meats, fatty foods, and desserts had an increased risk by 4.7 fold. In contrast, boys and girls enjoying diet consisting of vegetables, fruits, olive oil, fish, grains, and nuts had a the risk decreased substantially.

The authors concluded that specific dietary patterns could be associated with higher or lower risks for Crohn’s disease in children.

Do you or someone you know has Crohn’s disease? What are your thoughts on the relationship of diet and Crohn’s disease or ulcerative colitis?

Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

 

Confused about probiotics on market? Knowledge is power	Coconut oil for healthy, beautiful skin
Evidence based natural treatments of fibromyalgia	Gift of health "Natural Stomach Care"
Herb/spice in kitchen to prevent cancer & boost immunity	Yoga improves blood pressure & diabetes
Food triggers for migraine	Botox works at both ends. Cheers!
Fish type, mercury toxicity risks versus benefits	How to stop heartburn?
Depressed? Want alternative medicine options?	Risks of heartburn and ulcer medications
Constipation? Think your colon has kinks?	What causes alcohol hangover?

Is It Leaky Gut or Leaky Gut Syndrome?

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Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

What is colitis, diverticulitis and diverticulosis?

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Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

Colitis, diverticulitis and diverticulosis are not the same

Terms like colitis, diverticulitis, diverticulosis and irritable bowel syndrome, spastic colon can be confusing. Colitis, diverticulitis, IBS, irritable bowel syndrome, spastic colon although different are often used interchangeably by some people.

Colitis

Colitis means inflammation of the colon or large intestines. Colitis may be acute or chronic and may occur due to infections, drugs, toxins, ischemia, radiation therapy etc. Colitis may also be a manifestation of chronic IBD or idiopathic inflammatory bowel disease (ulcerative colitis and Crohn’s disease).

Diverticulosis

Diverticulosis is the presence of divertculi (plural for diverticulum), usually in the colon. The colonic divertculosis is very common in the western society presumably because of lack of fiber in diet.

As many as 50% or more may have colonic diverticulosis by the age of 50 years and this number may exceed 80% by the time one reaches the age of 80 years. Usually these diverticuli are asymptomatic and an incidental finding on barium enema or colonoscopy.

In a minority of cases, they may cause complications such as diverticulitis and gastrointestinal bleeding etc which may even become life-threatening.

Is It Leaky Gut or Leaky Gut Syndrome?

Diverticulitis

Diverticulitis occurs as a result of micro-perforation in the colon at the site of diverticulum. It is usually on the left side of colon and usually contained giving rise to localized infection and inflammation. This usually responds to medical measures including antibiotics. Interventional radiology techniques are sometimes used.

At times, such a perforation may form an abscess, cause bacteremia and become even become life-threatening. Surgery may be needed in severe cases.

Diverticular bleed

Diverticular bleed occurs more commonly from right sided diverticulosis. It is usually painless and massive and usually requires hospitalization and blood transfusions.

Majority of such bleeds stop spontaneously. Endoscopic and interventional radiology techniques can help stop bleeding in some cases, otherwise they may need surgery. Recurrent cases may need surgery.

Do you or someone you know has colitis or diverticulosis? What has been your experience with these terms? Please share your thoughts. 

Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

 

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Better clear liquid diet for Colonoscopy preparation

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Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

Colonoscopy or endoscopy of colon (large intestine) is often dreaded by some. Colonoscopy is also called lower GI scope and is different from barium enema. Colonic cleaning and clear liquid diet is needed as part preparation as a prelude to colonoscopy.

Colonoscopy as well as barium enema patients go through this misery of colonoscopy preparation on liquids like water or clear juices, carbonated beverages, electrolyte-rich sports drinks like Gatorade ®, flavored drinks e.g. Crystal-Light ®, Jello, sorbet and plain tea/coffee.

Lesser known fact is that there are clear nutritional supplements available that serve the purpose equally well and you would be less hungry since they also provide nutrition. These include Enlive ® (ww.rosstore.com), ResourceBreeze ® (ww.novartisnutrition.com), Ensure Clear and Carnation Instant Breakfast ® juice drink (www. Nestle-nutrition.com). Do not use regular Carnation Instant breakfast as part of clear liquid diet.

Mix-and-match the clear liquids with the clear liquids nutritional supplements and try your tasty mixed drinks such as slushies, ice-pops etc.

Caution: do not use anything any red, purple liquids.

Have you or someone you know has had a colonoscopy? What was your experience with clear liquid diet prior to the exam? 

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Do antioxidants lower cancer risk

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 Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

Antioxidants are frequently in news related to cancer. Experts differ on role of these antioxidants in health and sickness including cancer.

Antioxidants in esoohageal cancer

Antioxidants have been studied in esophageal cancer (cancer of esophagus) which is one of the fastest growing cancers in the US. Antioxidants as part of nutrition is a potentially modifiable factor in cancer. Use of antioxidants has been advocated but studies have been conflicting. Lack of antioxidants in the body has potential to increase risk for cancer through oxidative stress and DNA damage etc.

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Dr. Kubo and colleagues from University of Californiain San Fransisco recently conducted a meta-analysis of these studies and recently published their results in the American Journal of Gastroenterology 2007.

These investigators identified 10 studies. Summary estimates suggested that greater ingestion of anti-oxidants like vitamin C, beta-carotene or vitamin A, and vitamin E resulted in lower incidence of esophageal cancer. Individuals ingesting highest levels of beta-carotene/vitamin A or vitamin C had about 50% reduction in risk for cancer of esophagus. Vitamin E intake was however not helpful.

By the way, recent data suggested beneficial effect of beta-carotene in mental health also.

Of note, trials for use of antioxidant supplementation for cancer prevention in general (as opposed to diet rich in antioxidants) have frequently been disappointing and perhaps even increasing risk in some cases.

Do you take anti-oxidants or any other nutritional supplements? What are your thoughts on these supplements? Please feel free to share.

 

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Does botox works at both ends: check anal fissures

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 Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

You have heard about botox or botulinum toxin for skin wrinkles. Even botox parties are celebrated. Seems funny considering its use in anal fissure? By the way, botox or botulinum toxin has other uses too, like in achalasia, gastroparesis due to pyloric spasm etc.

Anal fissure

Anal fissure (different from hemorrhoids) can really be a pain the rear (no pun intended). Although acute anal fissures can be managed by conservative measures alone, the optimal medical treatment for chronic anal fissure is still lacking.

Is It Leaky Gut or Leaky Gut Syndrome?

Surgery is effective for treatment of chronic anal fissure but has significant morbidity.

Botox or botulinum toxin for anal fissures 

Recently, Brisinda and colleagues (Br J Surg 94:162-7) from Italy compared the efficacy of local nitroglycerin ointment versus botulinum toxin (botox).

Results

Botox group had superior healing rates at both 4 and 8 weeks. Adverse events were more likely to be due to nitroglycerin.

Bottomline

This finding of a comparison between two medical treatments must be interpreted in the context of data on comparison with placebo where nitroglycerin has only been marginally superior. In contrast, the efficacy of botox was similar to placebo.

Until long term studies can show superiority of botox over placebo, its use for routine treatment of chronic anal fissure may not be prudent.

Have you used botox for any reason? Do you or someone you know has chronic anal fissures? Please share the remedies that have or have not worked for you.

Here is info on botox or nitroglycerine for anal fissures.

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Is folic acid supplement good or bad ?

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 Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

Folic acid or folate supplementation is considered part of alternative medicine.Folate/folic acid is involved in numerous vital biochemical reactions in the body. Multiple studies have documented that folic acid supplementation during pregnancy reduces the risk of neural tube defects.

Folate/folic acid in cancer

Since folate deficiency may contribute to abnormal DNA synthesis, it has been widely believed that folic acid supplementation may help prevent certain cancers. Multiple previous studies including the Nurses Heart Study found beneficial effect of folic acid in colon but not breast cancer.

In contrast to the observational studies, results from a recent randomized controlled trial suggest that folic acid may actually be harmful and increase the risk of colon cancer. Cole and colleagues studied the role of folic acid supplementation in 1021 men and women with a recent history of colorectal adenomas. Repeat colonoscopy was done at 3 years and than 3 or 5 years later.

Is It Leaky Gut or Leaky Gut Syndrome?

The authors found that there was an increased risk of cancer/advanced colon lesions in the folic acid group. Interestingly, the investigators also found there was an increased risk of non-colonic cancers, primarily prostate cancer.

Interestingly, Lashner and  colleagues reported (1993) that higher folic acid levels increase risk for colon cancer in patients with ulcerative colitis. Subsequently, the same investigator based on his two other studies suggested that folic acid supplementation probably reduces risk of colon cancer in ulcerative colitis. Folic acid supplementation has been recommended in patients with ulcerative colitis.

Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

In recent years, the wheat flour and other grains have been fortified with folic acid. Interestingly, there has been a concomitant increase in colon cancer during the same period.

Pregnant females and those desiring pregnancy should continue to get folic acid supplementation. Recent data indicates that folic acid supplements are safe in this population. However, the policy of adding folic acid to wheat flour and grains may need to be re-evaluated. At the same time, so as to temper our enthusiasm for denigrating folic acid supplementation altogether, we have another recent study that documents that folic acid supplements reduce risk of stroke by 18 percent.

Do you take vitamin, mineral or other nutritional supplements? What are your thoughts on the literature about folate or folic acid and cancer. Certainly, one size does not fit all! Overall literature does seem to favor benefit. 

 Wall Street Journal Bestseller  Dr. M's Seven-X Plan for Digestive Health

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Black raspberries lower cancer risk

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Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

BLACK RASPBERRIES PREVENT CANCER

 Nutrition especially fruits like black raspberries can impact health including cancer. Yes, black raspberries may prevent cancer.

Is It Leaky Gut or Leaky Gut Syndrome?

Mechansim of black raspberries

Black raspberries are a rich natural source of chemopreventive phytochemicals and have been documented to prevent cancer of oral cavity, esophagus and colon in experimental animals.

The potential anti-cancer components of  raspberries include the following:

• Vitamins A, C, E and folic acid
• Calcium
• Selenium, beta and alfa carotene, lutein
• Polyphenols
• Phytosterols

Black raspberry extract prevents esophageal cancer by 40-60% and colon cancer by 60-80% in experimental models of these tumors in rodents.

Ethanol-extract of berries prevents ultra-violet induced skin cancer in mice.

In addition, black raspberries may lower blood cholesterol by up to 15 percent so may help reduce heart disease as well.

 Do you like raspberries? Are you likely to add or increase black raspberries in your diet? Please share your thoughts.

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DIET FOR CROHN'S DISEASE PATIENTS

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Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

A patient with Crohn's disease (aka regional enteritis which is one part of chronic inflammatory bowel disease, the other one being ulcerative colitis) asked me, "what kind of diet should I eat and what should I avoid?". By the way, the term Crohn's diease should not be confused with irritable bowel syndrome or diverticular disease.

Is It Leaky Gut or Leaky Gut Syndrome?

Diet, nutrition and Crohn's disease

The issue of diet in Crohn's disease is a tough one since there are not many good studies to help guide a recommendation. In general, it is a good idea to avoid anything that makes your gut go awry. In addition, I would suggest the following:

1. Studies  implicate diets rich in sugar, iron and aluminum in the pathogenesis of Crohn's disease. Thus, in the absence of evidence otherwise, it may be prudent to keep this in mind as we eat and drink everyday. 

• Avoid refined sugars which are abundant in sweets, candy and carbonated beverages.
• Talk to your doctor before taking iron supplements to make sure you indeed need them.
• Tea, and some herbs and leafy vegetables are high in aluminum naturally. Food processing contributes to aluminum in diet. Aluminum in diet may also come from food additives, bakery products, powdered foods and drinks, and processed cheeses. Aluminum in food may also be derived from aluminum utensils and cans/cartons. The degree to which these contribute to aluminum in food is controversial.

In most cases of flare up of Crohn's disease, it might be prudent to eat low fiber, low lactose diet and avoid irritants like alcohol, tomatoes, spicy foods, and caffeine.

Is It Leaky Gut or Leaky Gut Syndrome?

At the same time it should be noted that vegetarian diet provokes less inflammation than meat. In fact, a compromise  semi-vegetarian diet has been shown to be superior to healing Crohn's disease as compared to unrestricted meat diet.

Similar dietary precautions for Crohn's disease would apply to patients with ulcerative colitis also.

Most importantly, always talk to your doctor before imposing any dietary restrictions in any sort of health condition, including Crohn's disease or ulcerative colitis.

Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

 

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Is It Leaky Gut or Leaky Gut Syndrome?

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  Wall Street Journal Bestseller  Dr. M's Seven-X Plan for Digestive Health

Bacteria for your infant's colic?

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  Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

Infantile colic is a difficult problem, vexing both to parents and physicians. The cause is thought to be excess intestinal gas. On the lines of irritable bowel syndrome or IBS, new research indicates that probiotic bacteria help in kids with colic.

Probiotics or "good bacteria" that tend to maintain a healthy balance of good versus bad bacteria in the gut. They are being increasingly have been found to be useful for treatment of various illnesses, both gut and non-gut related.

Is It Leaky Gut or Leaky Gut Syndrome?

Probiotic-colic study

Dr. Savino and colleagues from the University of Turin in Italy conducted a randomized placebo controlled trial to study the effect of Lactobacillus reuteri. Their findings were published in the journal Pediatrics (January 2007).

The study cohort consisted of 90 breast fed babies who were administered either the probiotic or the common over the counter anti-gas medication known as simethicone for 28 days. Mothers refrained from ingesting cow's milk in their diet. Baby crying times were assessed.

 Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

Results of Probiotic-colic study

The daily median crying time at day 28 was 145 minutes/day in placebo group as compared to only 51 minutes/day in the probiotic group. 95% babies were termed as responders among the probiotic group in contrast to only 7% in the placebo group.

Comments

The mechanism of action of the probiotic in such conditions remains to be established. Possible mechanisms include immune-modulation and enhanced peristalsis thus affecting the balance of the gut flora and reduced triggers for abdominal pain. 

   Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

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Botox is good for constipation too!

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Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

Botulinum toxin or botox has been gaining increasing popularity as a cosmetic intervention for wrinkles in recent years. Even botox parties and get-togethers are held!

Now comes a study demonstrating that botox is good for constipation due to dysfunction of muscles of the pelvic floor.

Normally, such muscles are supposed to relax to facilitate dysfunction. In affected patients there is paradoxical contraction. This disorder is fairly common cause of constipation especially among females.

Is It Leaky Gut or Leaky Gut Syndrome?

Study

Dr. Maria and colleagues studied studied 24 women with functional outlet obstruction or functional obstructive defecation. Treatment involved injection of type A botulinum toxin. They published their findings in the American Journal of Gastroenterology .

Results

At 2-month follow-up, 19 of the 24 patients had improved defecation.

Conclusions

The authors concluded that botox is simple, safe and effective treatment for such patients with constipation.  

Are you familiar with botox? Do you or someone you know has had botox treatments? By the way, botox is used as a treatment for treatment of anal fissures also.

Wall Street Journal Best Seller Dr. M's Seven-X Plan for Digestive Health

 

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